RNDr. Michal Tichý, Ph.D.

e-mail: michal.tichy@uochb.cas.cz
phone: +420 220183343


Born 10. 10. 1984 in Brandýs nad Labem (Czech Republic).

Scientific CV:
2004-2007 undergraduate study, Charles University in Prague - Faculty of Science, Bc. S. degree - specialization clinical and toxicological analysis (supervisor RNDr. Jan Šarek, Ph.D.)
2007-2009 undergraduate study, Charles University in Prague - Faculty of Science, M. S. degree - specialization organic chemistry (supervisor RNDr. Jan Šarek, Ph.D.)
2009-2015 PhD study, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic (supervisor Dr. M. Hocek)
2015-2016 Postdoctoral stay, ETH Zürich (supervisor Prof. Dr. François Diederich)
2017 Postdoctoral stay, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic (supervisor Dr. M. Hocek)
since 2018 Scientist, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic (supervisor Dr. M. Hocek)

Awards:
2009 Zentiva award for the best diploma thesis (2nd position)

Grant projects:
2022-2025 National Institute for Cancer Research (Expert project guarantor for IOCB)

List of publications:

19.	Yang, C.; Tichý, M.; Poštová Slavĕtínská, L.; Vaiedelich, E.; Gurská, S.; Džubák, P.; Hajdúch, M.; Hocek, M.: "Synthesis and Biological Profiling of Benzofuro-Fused 7-Deazapurine Nucleosides" Eur. J. Org. 2023, e202300723.
18.	Yang, Ch.; Slavĕtínská Poštová, L.; Fleuti, M.; Klepetářová, B.; Tichý, M.; Gurská, S.; Pavliš, P.; Džubák, P.; Hajdúch, M. and Hocek, M.: "Synthesis of Polycyclic Hetero-Fused 7-Deazapurine Heterocycles and Nucleosides through C–H Dibenzothiophenation and Negishi Coupling" J. Am. Chem. Soc. 2022, 144 (42), 19437-19446.
17.	Sýkorová, V.; Tichý, M.; Hocek, M.: "Polymerase Synthesis of DNA Containing Iodinated Pyrimidine or 7-Deazapurine Nucleobases and Their Post-synthetic Modifications through the Suzuki-Miyaura Cross-Coupling Reactions" ChemBioChem 2022, 23, e202100608.
16.	Nguyen, V. H.; Tichý, M.; Rožánková, S.; Pohl, R.; Downey, M. A.; Doleželová, E.; Tlouštová, E.; Slapnicková, M.; Zíková, A.; Hocek, M.: "Synthesis and Anti-trypanosomal Activity of 3'-Fluororibonucleosides Derived from 7-Deazapurine Nucleosides" Bioorg. Med. Chem. Lett. 2021, 40, 127957.
15.	Veselovská, L.; Kudlová, N.; Gurská, S.; Lišková, B.; Medvedíková, M.; Hodek, O.; Tlouštová, E.; Milisavljevic, N.; Tichý, M.; Perlíková, P.; Mertlíková-Kaiserová, H.; Trylcová, J.; Pohl, R.; Klepetárová, B.; Džubák, P.; Hajdúch, M.; Hocek, M.: "Synthesis and Cytotoxic and Antiviral Activity Profiling of All-Four Isomeric Series of Pyrido-Fused 7-Deazapurine Ribonucleosides" Chem. Eur. J. 2020, 26, 13002-13015.
14.	Fleuti, M.; Bártová, K.; Poštová Slavetínská, L.; Tlouštová, E.; Tichý, M.; Gurská, S.; Pavliš, P.; Džubák, P.; Hajdúch, M.; Hocek, M.: "Synthesis and Biological Profiling of Pyrazolo-Fused 7-Deazapurine Nucleosides" J. Org. Chem. 2020, 85, 10539-10551.
13.	Yang, C.; Pohl, R.; Tichý, M.; Gurská, S.; Pavliš, P.; Džubák, P.; Hajdúch, M.; Hocek, M.: "Synthesis, Photophysical Properties, and Biological Profiling of Benzothieno-Fused 7-Deazapurine Ribonucleosides" J. Org. Chem. 2020, 85, 8085-8101.
12.	Malnuit, V.; Smoleń, S.; Tichý, M.; Poštová Slavětínská, L.; Hocek, M.: "Synthesis of Cyclic and Acyclic Nucleoside Phosphonates and Sulfonamides Derived from 6-(Thiophen-2-yl)-7-fluoro-7-deazapurine" Eur. J. Org. Chem. 2019, 5409-5423.
11.	Havlíčková, J.; Dolejšová, K.; Tichý, M.; Vrkoslav, V.; Kalinová, B.; Kyjaková, P.; Hanus, R.: "(3R,6E)-nerolidol, a fertility-related volatile secreted by the queens of higher termites (Termitidae: Syntermitinae)" Z. Naturforsch. 2019, 74(9-10)c, 251-264.
10.	Tokarenko, A.; Lišková, B.; Smoleń, S.; Táborská, N.; Tichý, M.; Gurská, S.; Perlíková, P.; Frydrych, I.; Tloušťová, E.; Znojek, P.; Mertlíková-Keiserová, H.; Poštová Slavětínská, L.; Pohl, R.; Klepetářová, B.; Khalid, N.; Wenren, Y.; Laposa, R. R.; Džubák, P.; Hajdúch, M.; Hocek, M.: "Synthesis and Cytotoxic and Antiviral Profiling of Pyrrolo- and Furo-Fused 7-Deazapurine Ribonucleosides" J. Med. Chem. 2018, 61, 9347-9359.
9.	Tichý, M.; Smoleń, S.; Deingruber, T.; Džubák, P.; Pohl, R.; Poštová Slavětínská, L.; Hajdúch, M.; Hocek, M.: "Thienopyrrolo[2, 3-d]pyrimidines, New Tricyclic Nucleobase Analogues: Synthesis and Biological Activities" ChemistrySelect 2018, 3, 9144-9149.
8.	Eignerová, B.; Tichý, M.; Krasulová, J.; Kvasnica, M.; Rárová, L.; Christová, R.; Urban, M.; Bednarczyk-Cwynar, B.; Hajdúch, M.; Šarek, J.: "Synthesis and antiproliferative properties of new hydrophilic esters of triterpenic acids" Eur. J. Med. Chem. 2017, 140, 403 - 420.
7.	Konč, J.; Tichý, M.; Pohl, R.; Hodek, J.; Džubák, P.; Hajdúch, M.; Hocek, M.: "Sugar modified pyrimido[4,5-b]indole nucleosides: synthesis and antiviral activity" Med. Chem. Commun. 2017, 8, 1856 - 1862.
6.	Kuhn, B.; Tichý, M.; Wang, L.; Robinson, S.; Martin, R. E.; Kuglstatter, A.; Benz, J.; Giroud, M.; Schirmeister, T.; Abel, R.; Diederich, F.; Hert, J.: "Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors" J. Med. Chem. 2017, 60, 2485 - 2497.
5.	Tichý, M.; Smoleń, S.; Tloušťová, E.; Pohl, R.; Oždian, T.; Hejtmánková, K.; Lišková, B.; Gurská, S.; Džubák, P.; Hajdúch, M.; Hocek, M.: "Synthesis and Cytostatic and Antiviral Profiling of Thieno-Fused 7-Deazapurine Ribonucleosides" J. Med. Chem. 2017, 60, 2411 - 2424.
4.	Bosáková, A.; Perlíková, P.; Tichý, M.; Pohl, R.; Hocek, M.: "6-Aryl-4-amino-pyrimido[4,5-b]indole 2'-deoxyribonucleoside triphosphates (benzo-fused 7-deaza-dATP analogues): Synthesis, fluorescent properties, enzymatic incorporation into DNA and DNA-protein binding study" Bioorg. Med. Chem. 2016, 24, 4528 - 4535.
3.	Tichý, M.; Pohl, R.; Tloušťová, E.; Weber, J.; Bahador, G.; Lee, Y.-J.; Hocek, M.: "Synthesis and biological activity of benzo-fused 7-deazaadenosine analogues. 5- and 6-substituted 4-amino- or 4-alkylpyrimido [4,5-b]indole ribonucleosides" Bioorg. Med. Chem. 2013, 21, 5362–5372.
2.	Tichý, M.; Pohl, R.; Xu, H. Y.; Chen, Y.-L.; Yokokawa, F.; Shi, P.-Y.; Hocek, M.: "Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides" Bioorg. Med. Chem. 2012, 20, 6123–6133.
1.	Krasulová, J.; Hanus, R.; Kutalová, K.; Šobotník, J.; Sillam-Dusse`s, D.; Tichý, M.; Valterová, I.: "Chemistry and Anatomy of the Frontal Gland in Soldiers of the Sand Termite Psammotermes hybostoma" J. Chem. Ecol. 2012, 38, 557–565.

Patents:

1.	Hocek, M.; Tichý, M.; Hajdúch, M.; Džubák, P.: "Substituted Thienopyrrolopyrimidine Ribornucleosides For Therapeutic Use"; Patent Application: WO 2018/001393 A1, 4th January 2018.