Dr. Michael Downey

e-mail: downey@uochb.cas.cz
phone: +420 220 183 343


Born 14.4.1986 in Calgary (Canada).

Scientific CV:
2004-2009 undergraduate study, University of Alberta, BSc degree - Specialisation Pharmacology, Industrial Internship Program (Supervisor: Dr. Christopher Cairo)
2009-2012 MSc study, University of Alberta, MSc degree - Specialisation Chemical Biology, (Supervisor: Dr. Christopher Cairo)
2013-2017 PhD study, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic (supervisor Dr. M. Hocek)
since 2018 Postdoctoral stay, Max Planck Institute of Colloids and Interfaces in Potsdam, (supervisor Prof. P. Seeberger)

Awards:
2017 Best oral presentation - ChemBioChem prize - SCNAC 2017, Český Krumlov, Czech Republic


Professional membership:
Canadian Society for Chemistry

List of publications:

7.	Nguyen, V. H.; Tichý, M.; Rožánková, S.; Pohl, R.; Downey, M. A.; Doleželová, E.; Tlouštová, E.; Slapnicková, M.; Zíková, A.; Hocek, M.: "Synthesis and Anti-trypanosomal Activity of 3'-Fluororibonucleosides Derived from 7-Deazapurine Nucleosides" Bioorg. Med. Chem. Lett. 2021, 40, 127957.
6.	Downey, A. M.; Hocek, M.: "Strategies toward protecting group-free glycosylation through selective activation of the anomeric center" Beilstein J. Org. Chem. 2017, 13, 1239-1279.
5.	Downey, A. M.; Pohl, R.; Roithová, J.; Hocek, M.: "Synthesis of Nucleosides through Direct Glycosylation of Nucleobases with 5-O-Monoprotected or 5-Modified Ribose: Improved Protocol, Scope, and Mechanism" Chem. Eur. J. 2017, 23, 3910-3917.
4.	Downey, A. M.; Richter, C.; Pohl, R.; Mahrwald, R.; Hocek, M.: "Direct One-Pot Synthesis of Nucleosides from Unprotected or 5-O-Monoprotected D-Ribose" Org. Lett. 2015, 17, 4604–4607.
3.	Downey, A.M.; Cairo, C.W.: "Synthesis of α-brominated phosphonates and their application as phosphate bioisosteres" Med. Chem. Commun. 2014, 5, 1619-1633.
2.	Downey, A.M.; Cairo, C.W.: "α-Bromophosphonate analogs of glucose-6-phosphate are inhibitors of glucose-6-phosphatase" Carbohydr. Res. 2013, 381, 123-132.
1.	Tulsi, N.S.; Downey, A.M.; Cairo, C.W.: "A protected L-bromophosphonomethylphenylalanine amino acid derivative (BrPmp) for synthesis of irreversible protein tyrosine phosphatase inhibitors" Bioorg. Med. Chem. 2010, 18, 8679-8686.

Patents:

1.	Cairo, C.W.; Tulsi N.S.; Downey, A.M.: "Preparation of bromophosphonomethylphenylalanine derivatives as irreversible inhibitors of protein tyrosine phosphatases" Patent Application PCT Int. Appl. 2011, WO 2011106898 (A1) 2011-09-09.