Dr. Filip Gracias

e-mail: filip.gracias@uochb.cas.cz
phone: +420 220 183 344


Born 12. 07. 1994 in Karlovy Vary (Czech Republic).

Scientific CV:
2013-2016 undergraduate study, University of Chemistry and Technology Prague, Faculty of Chemical Technology, B. Sc. degree - specialization Drug synthesis and production (supervisor Ing. Tomáš Martinů, Ph.D.)
2016-2018 undergraduate study, University of Chemistry and Technology Prague, Faculty of Chemical Technology, M. Sc. degree - specialization Organic Chemistry (supervisor doc. Tomáš Tobrman, Ph.D.)
2018-2025 PhD study, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic (supervisor Prof. Ing. Michal Hocek, CSc., DSc.)




List of publications:

4.	Gracias, F.; Pohl, R.; Sykorova, V.; Hocek, M.: "Bacteriophage-related epigenetic natural and non-natural pyrimidine nucleotides and their influence on transcription with T7 RNA polymerase" Commun. Chem. 2024, 7, 256.
3.	Pospíšil, Š.; Panattoni, A.; Gracias, F.; Sýkorová, V.; Hausnerová, V. V.; Vítovská, D.; Šanderová, H.; Krásný, L.; Hocek, M.: "Epigenetic Pyrimidine Nucleotides in Competition with Natural dNTPs as Substrates for Diverse DNA Polymerases" ACS Chem. Biol. 2022, 17 (10), 2781-2788.
2.	Gracias, F.; Ruiz-Larrabeiti, O.; Vanková Hausnerová, V.; Pohl, R.; Klepetárová, B.; Sýkorová, V.; Krásný, L.; Hocek, M.: "Homologues of epigenetic pyrimidines: 5-alkyl-, 5-hydroxyalkyl and 5-acyluracil and -cytosine nucleotides: synthesis, enzymatic incorporation into DNA and effect on transcription with bacterial RNA polymerase" RSC Chem. Biol. 2022, 3, 1069-1075.
1.	Gracias, F.; Dvořáková, H.; Martinů, T.: "The Beckmann fragmentation of quadricyclanone oxime" Tetrahedron Lett. 2017, 58, 682-684.