Hosek Research Team
Hosek Research Team
Hocek Research Team

Dr. Nicolas Joubert

Dr. Nicolas Joubert

e-mail: joubert@uochb.cas.cz

Born 17. 6. 1978 in Monaco.

Scientific CV:
1996-1999 Post secondary program leading to the nationwide competitive exam for admission to a graduate-level Engineering school (“Grande Ecole”), Lycée du Parc, Lyon, France
1999-2002 Diplôme d’ingénieur chimiste de l’ENSCCF (equivalent to master’s degree) in chemistry and chemical engineering awarded by the National School of Chemistry of Clermont Ferrand, France (supervisors : Prof. Yves Troin and Dr. Pierre Chalard)
2002 DEA (equivalent to master’s degree) in chemistry, with distinction, at the University Blaise Pascal of Clermont Ferrand, Aubiere, France (supervisors : Prof. Yves Troin)
2002-2005 Ph.D. studies in organic chemistry, with distinction, at the University of Orléans (supervisor : Prof. Luigi Agrofoglio)
2006-2008 Postdoctoral position at the Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic

2005 Best Oral Communication at the congress SECO 42 (Semaine d’Etude en Chimie Organique), Urrugne, France, May 2005. “Synthesis and biological evaluation of 5-haloethynyl- and 5-(1,2-dihalo)vinyluracil nucleosides.”
2005 Best Poster at Sciences en Sologne 2005, Orléans, May 2005. “Organic chemistry and hepatitis C : first steps toward a new treatment of the disease.”

Participation on projects: New methodologies for the synthesis of C nucleosides for extension of genetic alphabet.

List of publications:
10. Hari, Y.; Hwang, G. T.; Leconte, A. M.; Joubert, N.; Hocek, M.; Romesberg, F. E.: "Optimization of the Pyridyl Nucleobase Scaffold for Polymerase Recognition and Unnatural Base Pair Replication" ChemBioChem 2008, 9, 2796-2799.
9. Joubert, N.; Urban, M.; Pohl, R.; Hocek, M.: "Modular Synthesis of 4-Aryl- and 4-Amino-Substituted Benzene C-2'-Deoxyribonucleosides" Synthesis 2008, 1918-1932.
8. Joubert N.; Amblard, F.; Rapp, K. L.; Schinazi, R. F.; Agrofoglio, L.A.: "Synthesis and anti-HIV activity of 5-haloethynyl and 5-(1,2-dihalo)vinyl analogues of AZT and FLT" Tetrahedron 2008, 64, 4444-4452.
7. Broggi, J.; Joubert N.; Aucagne, V; Berteina-Raboin, S; Diez-Gonzales, S.; Nolan, S.; Topalis, D.; Deville-Bonne, D.; Balzarini, J.; Neyts, J.; Andrei, G.; Snoeck, R.; Agrofoglio L.A.: "Alkyne-Azide Click Chemistry Mediated Carbanucleosides Synthesis" Nucleosides, Nucleotides Nucleic Acids 2007, 26, 1391-1394.
6. Broggi, J.; Joubert N.; Aucagne, V; Zevaco, T.; Berteina-Raboin, S; Nolan, S.; Agrofoglio L.A.: "Study of Different Copper (I) Catalysts for the "Click Chemistry" Approach to Carbanucleosides" Nucleosides, Nucleotides Nucleic Acids 2007, 26, 779-783.
5. Joubert, N.; Pohl, R.; Klepetáøová, B.; Hocek, M.: "Modular and Practical Synthesis of 6-Substituted Pyridin-3-yl C-Nucleosides" J. Org. Chem. 2007, 72, 6797-6805.
4. Joubert, N.; Schinazi, R.F.; Agrofoglio, L.A.*: "Efficient Pd(0)-catalyzed Synthesis of 1,2,3-Triazolo Carbanucleosides and their Analogs" Tetrahedron 2005, 61, 11744-11750.
3. Escuret V., Aucagne V., Joubert N., Durantel D., Rapp K. L., Schinazi R.F., Zoulim F., Agrofoglio L.A.*: "5-Haloethynyl- and 5-(1,2-Dihalo)ethenyluracil Nucleosides: antiviral activities and cellular toxicities" Bioorg. Med. Chem. 2005, 13, 6015-6024.
2. Agrofoglio .L.A.*, Joubert N., Escuret V., Durantel D., Zoulim F. "The use of hcv replicon system for evaluation of new nucleoside analogs" in Framing the Knowledge of Viral Hepatitis. R.F. Schinazi, Eds., ihl Press? Arlington MA, USA (2005).
1. Agrofoglio L.A.*; Aucagne V.; Amblard F.; Joubert N.; Zoulim F.; Escuret V.; Durantel D.; Trepo C. "Uridine Derivatives as Antiviral Drugs against a Flaviviridae, especially HCV" Patent WO/2006/067606.
© Michal Hocek
Institute of Organic Chemistry and Biochemistry
Academy of Sciences of the Czech Republic