Hosek Research Team
Hosek Research Team
Hocek Research Team

Ing. Pavel Kielkowski, Ph.D.

Ing. Pavel Kielkowski, Ph.D.

e-mail: Pavel.Kielkowski@uochb.cas.cz
phone: +420 220183343

Born 27.4.1985 in Ostrava (Czech Republic).

Scientific CV:
2004-2009 undergraduate study, Institute of Chemical Technology Prague, M. S. degree - specialization chemistry of natural compounds (supervisor Associate professor Ladislav Kniežo)
2009-2014 PhD study, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic (supervisor Dr. M. Hocek)
since 2014 Postdoctoral stay, Technische Universität München (supervisor Prof. S. Sieber)

List of publications:
6.Cahová, H.; Panattoni, A.; Kielkowski, P.; Fanfrlík, J.; Hocek, M.: "5-Substituted Pyrimidine and 7-Substituted 7-Deazapurine dNTPs as Substrates for DNA Polymerases in Competitive Primer Extension in the Presence of Natural dNTPs" ACS Chem. Biol. 2016, 11, 3165 - 3171.
5. Kielkowski, P.; Cahová, H.; Pohl, R.; Hocek, M.: "Flexible double-headed cytosine-linked 2'-deoxycytidine nucleotides. Synthesis, polymerase incorporation to DNA and interaction with DNA methyltransferases" Bioorg. Med. Chem. 2016, 24, 1268 – 1276.
4. Kielkowski, P.; Fanfrlík, J.; Hocek, M.: 7-Aryl-7-deazaadenine 2'-Deoxyribonucleoside Triphosphates (dNTPs): Better Substrates for DNA Polymerases than dATP in Competitive Incorporations Angew. Chem. Int. Ed. 2014, 53, 7552 - 7555.
3. Kielkowski, P.; Brock, N. L.; Dickschat, J. S.; Hocek, M.: "Nucleobase Protection Strategy for Gene Cloning and Expression" ChemBioChem 2013, 14, 801-804.
2. Kielkowski, P.; Macíčková-Cahová, H.; Pohl, R.; Hocek, M.: "Transient and Switchable (Triethylsilyl)ethynyl Protection of DNA against Cleavage by Restriction Endonucleases" Angew. Chem. Int. Ed. 2011, 50, 8727 –8730.
1. Kielkowski, P.; Pohl, R.; Hocek, M.: "Synthesis of Acetylene Linked Double-Nucleobase Nucleos(t)ide Building Blocks and Polymerase Construction of DNA Containing Cytosines in the Major Groove" J. Org. Chem. 2011, 76, 3457–3462.
© Michal Hocek
Institute of Organic Chemistry and Biochemistry
Academy of Sciences of the Czech Republic