Hosek Research Team
Hosek Research Team
Hocek Research Team

Ing. Martin Klečka, Ph.D.

Ing. Martin Klečka, Ph.D.

e-mail: klecka@uochb.cas.cz
phone: +420 220 183 494


Born 30. 01. 1982 in Praha (Czech Republic).

Scientific CV:
2001-2007 undergraduate study, Prague Institute of Chemical Technology, M. S. degree - specialization organic chemistry (supervisor Prof. D. Dvořák)
2004-2005 study abroad University of Glasgow, Scotland, United Kingdom (supervisor prof. P. Kočovský)
2007-2008 PhD study, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic (supervisor Dr. M. Hocek)
2009-2011 research and development, AMGEN CZ
04/2011-2016 PhD study, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic (supervisor Prof. Dr. M. Hocek)
2016-2018 Postdoctoral stay, University of Southern Denmark and Technical University of Denmark (supervisor Ass. Prof. Kira Astakhova)
since 9/2018 Postdoctoral stay, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic (supervisor Dr. M. Hocek)

List of publications:
9. Klečka, M.; Thybo, C.; Macaubas, C.; Solov'yov, I.; Simard, J.; Balboni, I. M.; Fox, E.; Voss, A.; Mellins, E. D.; Astakhova, K.: "Autoantibody Profiling in Lupus Patients using Synthetic Nucleic Acids" Scientific Reports 2018, 8:5554.
8. Klečka, M.; Poštová Slavětínská, L.; Hocek, M.: "Modification of Pyrrolo[2,3-d]pyrimidines by C–H Borylation Followed by Cross-Coupling or Other Transformations: Synthesis of 6,8-Disubstituted 7-Deazapurine Bases" Eur. J. Org. Chem. 2015, 36, 7943 – 7961.
7. Klečka, M.; Slavětínská, L.; Tloušťová, E.; Džubák, P.; Hajdúch, M.; Hocek, M.: "Synthesis and cytostatic activity of 7-arylsulfanyl-7-deazapurine bases and ribonucleosides" Med. Chem. Commun. 2015, 6, 576–580.
6. Sabat, N.; Klečka, M.; Slavětínská, L.; Klepetářová, B.; Hocek, M.: "Direct C–H amination and C–H chloroamination of 7-deazapurines" RSC Adv. 2014, 4, 62140 – 62143.
5. Krömer, M.; Klečka, M.; Slavětínská, L.; Klepetářová, B.; Hocek, M.: "Chemoselective synthesis of 4,5-diarylpyrrolo[2,3-d]pyrimidines (6,7-diaryl-7-deazapurines) by consecutive Suzuki and Liebeskind-Srogl cross-couplings" Eur. J. Org. Chem. 2014, 32, 7203–7210.
4. Klečka, M.; Pohl, R.; Čejka, J.; Hocek, M.: "Direct C–H sulfenylation of purines and deazapurines" Org. Biomol. Chem. 2013, 11, 5189-5193.
3. Klečka, M.; Křováček, M.; Tobrman, T.; Dvořák, D.: "Synthesis of (E)-6-alkenylpurines via Pd-catalyzed stannation/protodestannation tandem process of alkynylpurines" Collect. Czech. Chem. Commun. 2010, 75, 313-332.
2. Klečka, M.; Pohl, R.; Klepetářová, B.; Hocek, M.: "Direct C–H borylation and C–H arylation of pyrrolo[2,3-d]pyrimidines: synthesis of 6,8-disubstituted 7-deazapurines" Org. Biomol. Chem. 2009, 7, 866-868.
1. Klečka, M.; Tobrman, T.; Dvořák, D.: "Cu(I)-Catalyzed Coupling of (9-Benzylpurin-6-yl)magnesium Chloride with Allyl Halides: an Approach to 6-Allylpurine Derivates" Collect. Czech. Chem. Commun. 2006, 71, 1221–1228.
© Michal Hocek
Institute of Organic Chemistry and Biochemistry
Academy of Sciences of the Czech Republic