Dr. Vincent Malnuit

e-mail: malnuit@uochb.cas.cz
phone: +420 220183343


Born 08.06.1984 France.

Scientific CV:
2004-2006 undergraduate study, National Polytechnic Institute of Chemistry, Toulouse, France, BSc. degree.
2006-2007 undergraduate study, National Engineering School of Chemistry, Montpellier, France, MSc. degree - specialization: organic and medicinal chemistry.
2007-2011 PhD. study, Institute of Chemistry, Nice Sophia Antipolis University, France (supervisor Dr. Rachid Benhida).
2012-June 2013 Postdoctoral position, Organic and Analytical Chemistry Institute of the University of Orleans, France (supervisor prof. Guillaumet) and Laboratoires Servier, Orleans, France (Dr. Lefoulon).
since July 2013 Postdoctoral position, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic (supervisor Dr. M. Hocek)


List of publications:

7.	Malnuit, V.; Smoleń, S.; Tichý, M.; Poštová Slavětínská, L.; Hocek, M.: "Synthesis of Cyclic and Acyclic Nucleoside Phosphonates and Sulfonamides Derived from 6-(Thiophen-2-yl)-7-fluoro-7-deazapurine" Eur. J. Org. Chem. 2019, 5409-5423.
6.	Matyašovský, J.; Perlíková, P.; Malnuit, V.; Pohl, R.; Hocek, M.: "2-Substituted dATP Derivatives as Building Blocks for Polymerase-Catalyzed Synthesis of DNA Modified in the Minor Groove" Angew. Chem. Int. Ed. 2016, 55, 15856 - 15859.
5.	Malnuit, V.; Slavětínská, L.; Nauš, P.; Džubák, P.; Hajdúch, M.; Stolaříková, J.; Snášel, J.; Pichová, I.; Hocek, M.: "2-Substituted 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Inhibition of Adenosine Kinases, and Antimycobacterial Activity" ChemMedChem 2015, 10, 1079 - 1093.
4.	Benhida, R. ; Auberger, P. ; Malnuit, V. ; Driowya, M. ; Puissant, A. ; Robert, G.: Process for the preparation of Acadesine derivatives as antitumor agents for the treatment of chronic myeloid leukemia" PCT Int. Appl. 2012, WO2012143624.
3.	Malnuit, V. ; Duca, M. ; Benhida, R.: "Targeting DNA base pair mismatch with artificial nucleobases. Advances and perspectives in triple helix strategy" Org. Biomol. Chem. 2011, 9, 326 - 336.
2.	Duca, M. ; Malnuit, V. ; Barbault, F. ; Benhida, R.: "Design of novel RNA ligands that bind stem-bulge HIV-1 TAR RNA" Chem. Commun. 2010, 46, 6162 - 6164.
1.	Malnuit, V. ; Duca, M. ; Manout, A. ; Bougrin, K. ; Benhida, R.: "Tandem Azide-Alkyne 1,3-Dipolar Cycloaddition/Electrophilic Addition: A Concise Three-Component Route to 4,5-Disubstituted Triazolyl-Nucleosides" Synlett 2009, 13, 2123 - 2128.