Hocek Research Team

Ing. Ján Matyašovský, PhD.

Ing. Ján Matyašovský

e-mail: matyasovsky@uochb.cas.cz
phone: +420 220183343

Born 05.01.1992 in Partizánske (Slovakia).

Scientific CV:
2010-2013 undergraduate study, Slovak University of Technology in Bratislava, Faculty of chemical and food technology, Bc.S. degree - specialization in Chemistry (supervisor Ing. Angelika Lásiková, PhD.).
2013-2015 undergraduate study, Slovak University of Technology in Bratislava, Faculty of chemical and food technology, M.Sc. degree - specialization in Organic Chemistry (supervisor Prof. Tibor Gracza, DrSc.).
since 2015 PhD study, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic (supervisor Dr. M. Hocek)

Awards:
2017 Best poster presentation - ChemBioChem prize - SCNAC 2017, Český Krumlov, Czech Republic

List of publications:

9.	Brunderová, M.; Havlíček, V.; Matyašovský, J.; Pohl, R.; Poštová Slavĕtínská, L.; Krömer, M. and Hocek, M.: "Expedient production of site specifically nucleobase-labelled or hypermodified RNA with engineered thermophilic DNA polymerases" Nat. Commun. 2024, 15, 3054.
8.	Matyašovský, J.; Tack, L.; Palágyi, A.; Kuba, M.; Pohl, R.; Kraus, T.; Güixens-Gallardo, P.; Hocek, M.: "Nucleotides bearing aminophenyl- or aminonaphthyl-3-methoxychromone solvatochromic fluorophores for the enzymatic construction of DNA probes for the detection of protein–DNA binding" Org. Biomol. Chem. 2021, 19, 9966-9974.
7.	Matyašovský, J.; Hocek, M.: "2-Substituted 2'-Deoxyinosine 5'-Triphosphates as Substrates for Polymerase Synthesis of Minor-Groove-Modified DNA and Effects on Restriction Endonuclease Cleavage" Org. Biomol. Chem. 2020, 18, 255-262.
6.	Matyašovský, J.; Hocek, M.: "2-Substituted 2'-Deoxyinosine 5'-Triphosphates as Substrates for Polymerase Synthesis of Minor-Groove-Modified DNA and Effects on Restriction Endonuclease Cleavage" Org. Biomol. Chem. 2020, 18, 255-262.
5.	Güixens-Gallardo, P.; Zawada, Z.; Matyašovský, J.; Dziuba, D.; Pohl, R.; Kraus, T.; Hocek.: "Brightly Fluorescent 2'-Deoxyribonucleoside Triphosphates Bearing Methylated Bodipy Fluorophore for in cellulo Incorporation to DNA, Imaging and Flow Cytometry" Bioconjug. Chem. 2018, 29, 3906 – 3912.
4.	Matyašovský, J.; Pohl, R.; Hocek, M.: "2-Allyl- and -propargylamino-dATPs for site-specific enzymatic introduction of a single modification in minor groove of DNA" Chem. Eur. J. 2018, 24, 14938-14941.
3.	Matyašovský, J.; Perlíková, P.; Malnuit, V.; Pohl, R.; Hocek, M.: "2-Substituted dATP Derivatives as Building Blocks for Polymerase-Catalyzed Synthesis of DNA Modified in the Minor Groove" Angew. Chem. Int. Ed. 2016, 55, 15856 - 15859.
2.	Dziuba, D.; Pospíšil, P.; Matyašovský, J.; Brynda, J.; Nachtigallová, D.; Pulíšek, L.; Pohl, R.; Hof, M.; Hocek, M.: "Solvatochromic fluorene-linked nucleoside and DNA as color-changing fluorescent probes for sensing interactions" Chem. Sci. 2016, 7, 5775 - 5785.
1.	Sabat, N.; Nauš, P.; Matyašovský, J.; Dziuba, D.; Poštová Slavětínská, L.; Hocek, M.: "Synthesis of Fluorescent 2-Substituted 6-(Het)aryl-7-deazapurineBases {4-(Het)aryl-pyrrolo[2,3-d]pyrimidines} by Aqueous Suzuki–Miyaura Cross-Coupling Reactions" Synthesis 2016, 48, 1029 - 1045.