M.Sc. Nemanja Milisavljević, PhD.

e-mail: nemanja@uochb.cas.cz
phone: +420 220183343


Born 20. 08. 1988 in Valjevo (Serbia).

Scientific CV:
2007-2012 undergraduate study, University of Novi Sad, B. Sc. degree - specialization in Biochemistry (supervisor Prof. Dr. Vera Ćirin-Novta)
June-August 2011 bachelor thesis, Institute of Advanced Chemistry of Catalonia in Barcelona, supervisor Prof. Dr. Angel Messeguer
2012-2013 undergraduate study, University of Rennes 1, M. Sc. degree - specialization in Molecular Catalysis and Green Chemistry (supervisor Dr. Veronique Guerchais)
2013-2020 PhD study, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic (supervisor Dr. M. Hocek)
since 2021 Postdoctoral stay, University of Montpellier (supervisor Dr. Francoise Debart)


List of publications:

6.	Vavřina, Z.; Perlíková, P.; Milisavljevic, N.; Chevrier, F.; Smola, M.; Smith, J.; Dejmek, M.; Havlíček, V.; Budešínský, M.; Liboska, R.; Vaneková, L.; Brynda, J.; Bouřa, E.; Řezáčová, P.; Hocek, M. and Birkuš,G.: "Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists" J. Med. Chem. 2022, 65 (20), 14082-14103.
5.	Perlíková, P.; Krajczyk, A.; Doleželová, E.; Slapnicková, M.; Milisavljevic, N.; Poštová Slavetínská, L.; Tlouštová, E.; Gurská, S.; Džubák, P; Hajdúch, M.; Zíková, A.; Hocek, M.: "Synthesis and Antitrypanosomal Activity of 6-Substituted 7-Methyl-7-deazapurine Nucleosides" ACS Infect. Dis. 2021, 7 (4), 917-926.
4.	Milisavljevic, N.; Konkolová, E.; Kozák, J.; Hodek, J.; Veselovská, L.; Sýkorová, V.; Cížek, K.; Pohl, R.; Eyer, L.; Svoboda, P.; Ružek, D.; Weber, J.; Nencka, R.; Boura, E.; Hocek, M.: "Antiviral Activity of 7-Substituted 7-Deazapurine Ribonucleosides, Monophosphate Prodrugs, and Triphoshates against Emerging RNA Viruses" ACS Infect. Dis. 2021, 7 (2), 471-478.
3.	Veselovská, L.; Kudlová, N.; Gurská, S.; Lišková, B.; Medvedíková, M.; Hodek, O.; Tlouštová, E.; Milisavljevic, N.; Tichý, M.; Perlíková, P.; Mertlíková-Kaiserová, H.; Trylcová, J.; Pohl, R.; Klepetárová, B.; Džubák, P.; Hajdúch, M.; Hocek, M.: "Synthesis and Cytotoxic and Antiviral Activity Profiling of All-Four Isomeric Series of Pyrido-Fused 7-Deazapurine Ribonucleosides" Chem. Eur. J. 2020, 26, 13002-13015.
2.	Milisavljevič, N.; Perlíková, P.; Pohl, R.; Hocek, M.: "Enzymatic synthesis of base-modified RNA by T7 RNA polymerase. A systematic study and comparison of 5-substituted pyrimidine and 7-substituted 7-deazapurine nucleoside triphosphates as substrates" Org. Biomol. Chem. 2018, 16, 5800-5807.
1.	Raindlová, V.; Janoušková, M.; Slavíčková, M.; Perlíková, P.; Boháčová, S.; Milisavljevič, N.; Šanderová, H.; Benda, M.; Barvík, I.; Krásný, L.; Hocek, M.: "Influence of major-groove chemical modifications of DNA on transcription by bacterial RNA polymerases" Nucleic Acids Res. 2016, 44, 3000 – 3012.