Hocek Research Team

Lucie Mužíková Čechová, PhD.

e-mail: lucie.cechova@uochb.cas.cz
phone: +420 220 183 434

Born 6. 3. 1989 in Prague, Czech republic.

Scientific CV:
2009-2013 undergraduate study, UCT Prague, Faculty of food and biochemical technology.
2013-2015 graduate study, UCT Prague, Faculty of food and biochemical technology, M.Sc. Specialization in chemistry of natural compounds and organic chemistry (supervisor Ing. Zlatko Janeba, PhD.).
2019-2020 researcher, SANTIAGO, custom chemicals – Chemical CRO in Prague.
2015-2022 PhD. study, UCT Prague, Faculty of food and biochemical technology, M.Sc. Specialization in organic chemistry (supervisor Ing. Zlatko Janeba, PhD.).
since 2023 Postdoctoral study, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic (supervisor Dr. M. Hocek).

List of publications:

19. Hruzíková, A.; Mužíková Cechová, L.; Štepánová, S.; Tucková, L.; Tichotová, M.; Ružicka, A.; Kašicka, V.; Procházková, E.: "A study of azopyrimidine photoswitches and their interaction with cyclodextrins: When the guest governs the type of accommodation at the host." Dye Pigm. 2023, 212, 111099.

18. Procházková, E.; Filo, J.; Mužíková Cechová, L.; Dracínský, M.; Císarová, I.; Janeba, Z.; Kawamura, I.; Naito, A.; Kubena, I.; Nádaždy, P.; Šiffalovic, P.; Cigán, M.: "Photoswitching of 5-phenylazopyrimidines in crystalline powders and thin films." Dye Pigm. 2022, 199, 110066.

17. Osifová, Z.; Socha, O.; Mužíková Cechová, L.; Šála, M.; Janeba, Z.; Dracínský, M.: "Hydrogen-Bonding Interactions of Methylated Adenine Derivatives." Eur. J. Org. Chem. 2021, 29, 4166-4173.

16. Cechová, L.; Filo, J.; Dracínský, M.; Slavov, Ch.; Sun, D.; Janeba, Z.; Slanina, T.; Wechtveitl, J.; Procházková, E.; Cigán, M.: "Polysubstituted 5-Phenylazopyrimidines: Extremely Fast Non-ionic Photochromic Oscillators." Angew. Chem. Int. Ed. 2020, 59, 15590-15594.

15. Štocek, J. R.; Bártová, K.; Cechová, L.; Šála, M.; Socha, O.; Janeba, Z.; Dracínský, M.: "Determination of nucleobase-pairing free energies from rotamer equilibria of 2-(methylamino)pyrimidines." Chem. Commun. 2019, 55, 11075-11078.

14. Cechová, L.; Dejmek, M.; Baszczynski, O.; Šaman, D.; Gao, L.; Hu, E.; Stepan, G.; Jansa, P.; Janeba, Z.; Šimon, P.: "Synthesis and anti-human immunodeficiency virus activity of substituted (o,o-difluorophenyl)-linked-pyrimidines as potent non-nucleoside reverse transcriptase inhibitors." Antiviral Chem. Chemother. 2019, 27, 1-18.

13. Procházková, E.; Cechová, L.; Kind, J.; Janeba, Z.; Thiele, Ch. M.; Dracínský, M.: "Photoswitchable Intramolecular Hydrogen Bonds in 5-Phenylazopyrimidines Revealed By In Situ Irradiation NMRSpectroscopy." Chem. Eur. J. 2018, 24, 492-498.

12. Cechová, L.; Kind J., Dracínský, M.; Filo, J.; Janeba, Z.; Thiele, Ch. M.; Cigán, M.; Procházková, E.: "Photoswitching Behavior of 5-Phenylazopyrimidines: In Situ Irradiation NMR and Optical Spectroscopy Combined with Theoretical Methods." J. Org. Chem. 2018, 83, 5986-5998.

11. Štepánová, S.; Procházková, E.; Cechová, L.; Žurek, J.; Janeba, Z.; Dracínský, M.; Kašicka, V.: "Separation of rotamers of 5-nitrosopyrimidines and estimation of binding constants of their complexes with beta-cyclodextrin by capillary electrophoresis." J. Chromatogr. A 2018, 1570, 164-171.

10. Bártová, K.; Cechová, L.; Procházková, E.; Socha, O.; Janeba, Z.; Dracínský, M.: "Influence of Intramolecular Charge Transfer and Nuclear Quantum Effects on Intramolecular Hydrogen Bonds in Azopyrimidines." J. Org. Chem. 2017, 82, 10350-10359.

9. Procházková, E.; Cechová, L.; Tabárek, J.; Janeba, Z.; Dracínský, M.: "Tunable Push-Pull Interactions in 5-Nitrosopyrimidines." J. Org. Chem. 2016, 81, 3780-3789.

8. Jansa, P.; Cechová, L.; Janeba, Z.: "A Complete Degradation of Organophosphates by Microwave-Assisted Hydrolysis." Curr. Microwave Chem. 2016, 3, 219-226.

7. Dracínský, M.; Cechová, L.; Hodgkinson, P.; Procházková, E.; Janeba, Z.: "Resonance-assisted stabilisation of hydrogen bonds probed by NMR spectroscopy and path integral molecular dynamics." Chem. Comm. 2015, 51, 13986-13989.

6. Cechová, L.; Procházková, E.; Císarová, I.; Dracínský, M.; Janeba, Z.: "Separation of planar rotamers through intramolecular hydrogen bonding in polysubstituted 5-nitrosopyrimidines" Chem. Comm. 2014, 50, 14892-14895.

5. Jansa, P.; Cechová, L.; Dracínský, M.; Janeba, Z.: "A conversion of aromatic thiocyanates into sulfothioates: new synthetic route to aromatic Bunte salts" RSC Advances 2013, 3, 2650-2654.

4. Procházková, E.; Cechová, L.; Janeba, Z.; Dracínský, M.: "A Switchable Intramolecular Hydrogen Bond in Polysubstituted 5-Nitrosopyrimidines." J. Org. Chem. 2013, 78, 10121-10133.

3. Cechová, L.; Jansa, P.; Šála, M.; Dracínský, M.; Holý, A.; Janeba, Z.: "The optimized microwave-assisted decomposition of formamides and its synthetic utility in the amination reactions of purines" Tetrahedron 2012, 67, 866-871.

2. Procházková, E.; Cechová, L.; Jansa, P.; Dracínský, M.: "Long-range heteronuclear coupling constants in 2,6-disubstituted purine derivatives." Magn. Reson. Chem. 2012, 50, 295-298.

1. Procházková, E.; Jansa, P.; Brezinová, A.; Cechová, L.; Mertlíková-Keiserová, H.; Holý, A.; Dracínský, M.: "Compound instability in dimethyl sulphoxide, case studies with 5-aminopyrimidines and the implications for compound storage and screening." Bioorg. Med. Chem. 2012, 22, 6405-6409.

19.	Hruzíková, A.; Mužíková Cechová, L.; Štepánová, S.; Tucková, L.; Tichotová, M.; Ružicka, A.; Kašicka, V.; Procházková, E.: "A study of azopyrimidine photoswitches and their interaction with cyclodextrins: When the guest governs the type of accommodation at the host." Dye Pigm. 2023, 212, 111099.
18.	Procházková, E.; Filo, J.; Mužíková Cechová, L.; Dracínský, M.; Císarová, I.; Janeba, Z.; Kawamura, I.; Naito, A.; Kubena, I.; Nádaždy, P.; Šiffalovic, P.; Cigán, M.: "Photoswitching of 5-phenylazopyrimidines in crystalline powders and thin films." Dye Pigm. 2022, 199, 110066.
17.	Osifová, Z.; Socha, O.; Mužíková Cechová, L.; Šála, M.; Janeba, Z.; Dracínský, M.: "Hydrogen-Bonding Interactions of Methylated Adenine Derivatives." Eur. J. Org. Chem. 2021, 29, 4166-4173.
16.	Cechová, L.; Filo, J.; Dracínský, M.; Slavov, Ch.; Sun, D.; Janeba, Z.; Slanina, T.; Wechtveitl, J.; Procházková, E.; Cigán, M.: "Polysubstituted 5-Phenylazopyrimidines: Extremely Fast Non-ionic Photochromic Oscillators." Angew. Chem. Int. Ed. 2020, 59, 15590-15594.
15.	Štocek, J. R.; Bártová, K.; Cechová, L.; Šála, M.; Socha, O.; Janeba, Z.; Dracínský, M.: "Determination of nucleobase-pairing free energies from rotamer equilibria of 2-(methylamino)pyrimidines." Chem. Commun. 2019, 55, 11075-11078.
14.	Cechová, L.; Dejmek, M.; Baszczynski, O.; Šaman, D.; Gao, L.; Hu, E.; Stepan, G.; Jansa, P.; Janeba, Z.; Šimon, P.: "Synthesis and anti-human immunodeficiency virus activity of substituted (o,o-difluorophenyl)-linked-pyrimidines as potent non-nucleoside reverse transcriptase inhibitors." Antiviral Chem. Chemother. 2019, 27, 1-18.
13.	Procházková, E.; Cechová, L.; Kind, J.; Janeba, Z.; Thiele, Ch. M.; Dracínský, M.: "Photoswitchable Intramolecular Hydrogen Bonds in 5-Phenylazopyrimidines Revealed By In Situ Irradiation NMRSpectroscopy." Chem. Eur. J. 2018, 24, 492-498.
12.	Cechová, L.; Kind J., Dracínský, M.; Filo, J.; Janeba, Z.; Thiele, Ch. M.; Cigán, M.; Procházková, E.: "Photoswitching Behavior of 5-Phenylazopyrimidines: In Situ Irradiation NMR and Optical Spectroscopy Combined with Theoretical Methods." J. Org. Chem. 2018, 83, 5986-5998.
11.	Štepánová, S.; Procházková, E.; Cechová, L.; Žurek, J.; Janeba, Z.; Dracínský, M.; Kašicka, V.: "Separation of rotamers of 5-nitrosopyrimidines and estimation of binding constants of their complexes with beta-cyclodextrin by capillary electrophoresis." J. Chromatogr. A 2018, 1570, 164-171.
10.	Bártová, K.; Cechová, L.; Procházková, E.; Socha, O.; Janeba, Z.; Dracínský, M.: "Influence of Intramolecular Charge Transfer and Nuclear Quantum Effects on Intramolecular Hydrogen Bonds in Azopyrimidines." J. Org. Chem. 2017, 82, 10350-10359.
9.	Procházková, E.; Cechová, L.; Tabárek, J.; Janeba, Z.; Dracínský, M.: "Tunable Push-Pull Interactions in 5-Nitrosopyrimidines." J. Org. Chem. 2016, 81, 3780-3789.
8.	Jansa, P.; Cechová, L.; Janeba, Z.: "A Complete Degradation of Organophosphates by Microwave-Assisted Hydrolysis." Curr. Microwave Chem. 2016, 3, 219-226.
7.	Dracínský, M.; Cechová, L.; Hodgkinson, P.; Procházková, E.; Janeba, Z.: "Resonance-assisted stabilisation of hydrogen bonds probed by NMR spectroscopy and path integral molecular dynamics." Chem. Comm. 2015, 51, 13986-13989.
6.	Cechová, L.; Procházková, E.; Císarová, I.; Dracínský, M.; Janeba, Z.: "Separation of planar rotamers through intramolecular hydrogen bonding in polysubstituted 5-nitrosopyrimidines" Chem. Comm. 2014, 50, 14892-14895.
5.	Jansa, P.; Cechová, L.; Dracínský, M.; Janeba, Z.: "A conversion of aromatic thiocyanates into sulfothioates: new synthetic route to aromatic Bunte salts" RSC Advances 2013, 3, 2650-2654.
4.	Procházková, E.; Cechová, L.; Janeba, Z.; Dracínský, M.: "A Switchable Intramolecular Hydrogen Bond in Polysubstituted 5-Nitrosopyrimidines." J. Org. Chem. 2013, 78, 10121-10133.
3.	Cechová, L.; Jansa, P.; Šála, M.; Dracínský, M.; Holý, A.; Janeba, Z.: "The optimized microwave-assisted decomposition of formamides and its synthetic utility in the amination reactions of purines" Tetrahedron 2012, 67, 866-871.
2.	Procházková, E.; Cechová, L.; Jansa, P.; Dracínský, M.: "Long-range heteronuclear coupling constants in 2,6-disubstituted purine derivatives." Magn. Reson. Chem. 2012, 50, 295-298.
1.	Procházková, E.; Jansa, P.; Brezinová, A.; Cechová, L.; Mertlíková-Keiserová, H.; Holý, A.; Dracínský, M.: "Compound instability in dimethyl sulphoxide, case studies with 5-aminopyrimidines and the implications for compound storage and screening." Bioorg. Med. Chem. 2012, 22, 6405-6409.