Hocek Research Team

Mgr. Petr Nauš, Ph.D.

e-mail: naus@uochb.cas.cz
phone: +420 220183343

Born 21. 4. 1974 in Teplice (Czech Republic).

Scientific CV:
1992-1997 undergraduate study, Charles University in Prague - Faculty of Science, M. S. degree - specialization organic chemistry (supervisor Dr. Elbert)
1997-2003 PhD study, Charles University in Prague - Faculty of Science (supervisor Dr. L. Lešetický)
- Synthesis of radiolabeled photoaffinity probes.
2003-2004 Group member
2004-2006 Postdoctoral fellow on Department of Bioorganic Chemistry Uppsala University
since 2006 Group member

List of publications:

16.	Sabat, N.; Smoleń, S.; Nauš, P.; Perlíková, P.; Cebová, M.; Poštová Slavětínská, L.; Hocek, M.: "Synthesis of 2,6-Substituted 7-(Het)aryl-7-deazapurine Nucleobases (2,4-Disubstituted 5-(Het)aryl-pyrrolo[2,3-d]pyrimidines)" Synthesis 2017, 49, 4623 - 4650.
15.	Perlíková, P.; Rylová, G.; Nauš, P.; Elbert, T.; Tloušťová, E.; Bourderioux, A.; Poštová Slavětínská, L.; Motyka, K.; Doležal, D.; Znojek, P.; Nová, A.; Harvanová, M.; Džubák, P.; Šiller, M.; Hlaváč, J.; Hajdúch, M.; Hocek, M.: "7-(2-Thienyl)-7-Deazaadenosine (AB61), a New Potent Nucleoside Cytostatic with a Complex Mode of Action" Mol. Cancer Ther. 2016, 15, 922 – 937.
14.	Sabat, N.; Nauš, P.; Matyašovský, J.; Dziuba, D.; Poštová Slavetínská, L.; Hocek, M.: "Synthesis of Fluorescent 2-Substituted 6-(Het)aryl-7-deazapurineBases {4-(Het)aryl-pyrrolo[2,3-d]pyrimidines} by Aqueous Suzuki–Miyaura Cross-Coupling Reactions" Synthesis 2016, 48, 1029 – 1045.
13.	Nauš, P.; Caletková, O.; Perlíková, P.; Slavětínská, L.; Tloušťová, E.; Hodek, J.; Weber, J.; Džubák, P.; Hajdúch, M.; Hocek, M.: "Synthesis and biological profiling of 6- or 7-(het)aryl-7-deazapurine 4'-C-methylribonucleosides" Bioorg. Med. Chem. 2015, 23, 7422 – 7438.
12.	Malnuit, V.; Slavětínská, L.; Nauš, P.; Džubák, P.; Hajdúch, M.; Stolaříková, J.; Snášel, J.; Pichová, I.; Hocek, M.: "2-Substituted 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Inhibition of Adenosine Kinases, and Antimycobacterial Activity" ChemMedChem 2015, 10, 1079–1093.
11.	Snášel, J.; Nauš, P.; Dostál, J.; Hnízda, A.; Fanfrlík, J.; Brynda, J.; Bourderioux, A.; Dušek, M.; Dvořáková, H.; Stolaříková, J.; Zábranská, H.; Pohl, R.; Konečný, P.; Džubák, P.; Votruba, I.; Hajdúch, M.; Řezáčová, P.; Veverka, V.; Hocek, M.; Pichová, I.: "Structural basis for inhibition of mycobacterial and human adenosine kinase by 7-substituted 7-(het)aryl-7-deazaadenine ribonucleosides" J. Med. Chem. 2014, 57, 8268 – 8279.
10.	Nauš,P.; Caletková, O.; Konečný, P.; Džubák, P.; Bogdanová, K.; Kolář, M.; Vrbková, J.; Slavětínská, L.; Tloušťová, E.; Perlíková, P.; Hajdúch, M.; Hocek, M.: "Synthesis, Cytostatic, Antimicrobial, and Anti-HCV Activity of 6-Substituted 7-(Het)aryl-7-deazapurine Ribonucleosides" J. Med. Chem. 2014, 57, 1097 – 1110.
9.	Perlíková, P.; Konečný, P.; Nauš, P.; Snášel, J.; Votruba, I.; Džubák, P.; Pichová, I.; Hajdúch, M.; Hocek, M.: "6-Alkyl-, 6-aryl- or 6-hetaryl-7-deazapurine ribonucleosides as inhibitors of human or MTB adenosine kinase and potential antimycobacterial agents" Med. Chem. Commun. 2013, 4, 1497 – 1500.
8.	Nauš, P.; Perlíková, P.; Bourderioux, A.; Pohl, R.; Slavětínská, L.; Votruba, I.; Bahador, G.; Birkuš, G.; Cihlář, T.; Hocek, M.: "Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2'-C-methylribonucleosides, 2'-deoxy-2'-fluoroarabinonucleosides, arabinonucleosides and 2'-deoxyribonucleosides" Bioorg. Med. Chem. 2012, 20, 5202–5214.
7.	Bourderioux, A.; Nauš, P.; Perlíková, P.; Pohl, R.; Pichová, I.; Votruba, I.; Džubák, P.; Konečný, P.; Hajdúch, M.; Stray, K.M.; Wang, T.; Ray, A.S.; Feng, J.Y.; Birkus, G.; Cihlar, T.; Hocek, M.: "Synthesis and Significant Cytostatic Activity of 7-Hetaryl-7-deazaadenosines" J. Med. Chem. 2011, 54, 5498–5507.
6.	Nauš, P.; Perlíková, P.; Pohl, R.; Hocek, M.: "Sugar-modified derivatives of cytostatic 6-(het)aryl-7-deazapurine nucleosides: 2'- C -methylribonucleosides, arabinonucleosides and 2'-deoxy-2'-fluoroarabinonucleosides" Collect. Czech. Chem. Commun. 2011, 76, 957–988.
5.	Spáčilová, P.; Nauš, P.; Pohl, R.; Votruba, I.; Snášel, J.; Zábranská, H.; Pichová, I.; Ameral, R.; Birkuš, G.; Cihlář, T.; Hocek, M.: "CycloSal-phosphate Pronucleotides of Cytostatic 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases " ChemMedChem 2010, 5, 1386–1396.
4.	Nauš, P.; Pohl, R.; Votruba, I.; Džubák, P.; Hajdúch, M.; Ameral, R.; Birkus, G.; Wang, T.; Ray, A.S.; Mackman, R.; Cihlar, T.; Hocek, M.: "6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic Agents" J. Med. Chem. 2010, 53, 460–470.
3.	Nauš, P.; Kuchař, M.; Hocek, M.: "Cytostatic and activiral 6-arylpurine ribonucleosides IX. Synthesis and evaluation of 6-substituted 3-deazapurine ribonuclesides" Collect. Czech. Chem. Commun. 2008, 73, 665–678.
2.	Hocek, M.; Nauš, P.; Pohl, R.; Votruba, I.; Furman, P. A.; Tharnish, P. M.; Otto, M. J.: "Cytostatic 6-Arylpurine Nucleosides. 6. SAR in Anti-HCV and Cytostatic Activity of Extended Series of 6-Hetarylpurine Ribonucleosides" J. Med. Chem. 2005, 48, 5869–5873.
1.	Nauš, P.; Votruba, I.; Hocek, M.: "Covalent Analogues of DNA Base-Pairs and Triplets VII. Synthesis and Cytostatic Activity of Bis(purin-6-yl)acetylene and -diacetylene Nucleosides" Collect. Czech. Chem. Commun. 2004, 69, 1955–1970.