Hocek Research Team

RNDr. Marek Ondruš, Ph.D.

Marek Ondruš

e-mail: marek.ondrus@uochb.cas.cz

phone: +420 220 183 344, +421 910 615 120

Born 18. 02. 1992 in Žilina, Slovakia.

Scientific CV:

2011-2014 undergraduate study, Comenius University in Bratislava, Faculty of Science, Slovakia, B.Sc. Specialization in Biochemistry.

2014-2016 postgraduate study, Comenius University in Bratislava, Faculty of Science, Slovakia, M.Sc. Specialization in Organic and Bioorganic Chemistry.

2016-2023 Ph.D. Study, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic (supervisor Prof. Hocek).

since 2023 Project manager / postdoctoral research, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic (Prof. Hocek).

List of publications:

10.	Ondruš, M.; Franco-Urquijo, P. A.; Lerga, T. M.; Mužíková Cechová, L.; Bermudo Redondo, M. C.; O´Sullivan, C. K. and Hocek, M.: "Versatile enzymatic approach for truncation, labeling, and mutation of nucleobase-modified aptamers demonstrated on indole-modified ß-conglutin aptamer" ChemBioChem 2025, 26(20), e202500534.
9.	Kaiser, L.; Ondruš, M.; Poštová Slavĕtínská, L.; Raindlová, V.; Hocek, M.: "Polymerase Synthesis of Hypermodified DNA Displaying a Combination of Thiol, Hydroxyl, Carboxylate, and Imidazole Functional Groups in the Major Groove" Chem. Eur. J. 2025, e202501034.
8.	Kuprikova, N.; Ondruš, M.; Bednárová, L.; Kraus, T.; Poštová Slavĕtínská, L.; Sýkorová, V.; Hocek, M.: "Zwitterionic DNA: enzymatic synthesis of hypermodified DNA bearing four different cationic substituents at all four nucleobases" Nucleic Acids Res. 2025, 53 (5), gkaf155.
7.	Ivancová, I.; Sanchez Quirante, T.; Ondruš, M.; Pohl, R.; Vlková, M.; Žilecká, E.; Bouřa, E. and Hocek, M.: "Enzymatic synthesis of reactive RNA probes containing squaramate-linked cytidine or adenosine for bioconjugations and cross-linking with lysine-containing peptides and proteins" Commun. Chem. 2025, 8, 1.
6.	Kuprikova, N.; Ondruš, M.; Bednárová, L.; Riopedre Fernández, M.; Poštová Slavĕtínská, L.; Sýkorová, V.; Hocek, M.: "Superanionic DNA. Enzymatic Synthesis of Hypermodified DNA Bearing Four Different Anionic Substituents at all Four Nucleobases" Nucleic Acids Res. 2023, 51 (21), 11428-11438.
5.	Mulholland, C.; Jestřábová, I.; Sett, A.; Ondruš, M.; Sýkorová, V.; Manzanares, C. L.; Šimoncík, O.; Muller, P. and Hocek, M.: "The selection of a hydrophobic 7-phenylbutyl-7-deazaadenine-modified DNA aptamer with high binding affinity for the Heat Shock Protein 70" Commun. Chem. 2023, 6, 65.
4.	Ondruš, M.; Sýkorová, V.; Hocek, M.: "Traceless enzymatic synthesis of monodispersed hypermodified oligodeoxyribonucleotide polymers from RNA templates" Chem. Commun. 2022, 58, 11248-11251.
3.	Ondruš, M.; Sýkorová, V.; Bednárová, L.; Pohl, R.; Hocek, M.: "Enzymatic Synthesis of Hypermodified DNA Polymers for Sequence-Specific Display of Four Different Hydrophobic Groups" Nucleic Acids Res. 2020, 48 (21), 11982-11993.
2.	Dobiaš, J.; Ondruš, M.; Hlavác, M.; Murár, M.; Kóna, J.; Addová, G.; Bohác, A.: "Medicinal chemistry: an effect of a desolvation penalty of an amide group in the development of kinase inhibitors." Chem. Pap. 2019, 73, 71-84.
1.	Dobiaš, J.; Ondruš, M.; Addová, G.; Bohác, A.: "Switchable highly regioselective synthesis of 3,4-dihydroquinoxaline-2(1H)ones from o-phenylenediamines and aroylpyruvates." Beilstein J. Org. Chem. 2017, 13, 1350-1360.