Hosek Research Team
Hosek Research Team
Hocek Research Team

Ing. Milan Vrábel, Ph.D.

Ing. Milan Vrábel, Ph.D.

e-mail: vrabel@uochb.cas.cz

Born 30. 7. 1981 in Šala (Slovak Republic).

Scientific CV:
1999-2004 undergraduate study, Slovak University of Technology in Bratislava, M. S. degree - specialization organic chemistry (supervisor Prof. Fišera)
2004-2008 PhD study, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic (supervisor Dr. M. Hocek)
2008-2014 Postdoctoral stay, Ludwig-Maximilians-Universität, München, Carell Group
since 2014 Junior Group Leader in Bioorganic and Medicinal Chemistry, ERC Grant funding, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic

ERC Grant

List of publications:
7. Ménová, P.; Vrábel, M.; Cahová, H.; Hocek, M.: "Synthesis of base-modified dNTPs through cross-coupling reactions and their polymerase incorporation to DNA" (Book Chapter), in Non-Natural Nucleic Acids: Methods and Protocols, Methods in Molecular Biology (N. Shank ed.), Humana Press, New York, NY, 2019, vol. 1973, pp. 39-57.
6. Vrábel, M.; Horáková, P.; Pivoňková, H.; Kalachova, L.; Černocká, H.; Cahová, H.; Pohl, R.; Šebest, P.; Havran, L.; Hocek, M.; Fojta, M.: "Base-Modified DNA Labeled by [Ru(bpy)3]2+ and [Os(bpy)3]2+ Complexes: Construction by Polymerase Incorporation of Modified Nucleoside Triphosphates, Electrochemical and Luminescent Properties, and Applications" Chem. Eur. J. 2009, 15, 1144-1154.
5. Vrábel, M.; Pohl, R.; Votruba, I.; Sajadi, M.; Kovalenko, S. A.; Ernsting, N. P.; Hocek, M.: "Synthesis and photophysical properties of 7-deaza-2'-deoxyadenosines bearing bipyridine ligands and their Ru(II)-complexes in position 7" Org. Biomol. Chem. 2008, 6, 2852-2860.
4. Brázdilová, P.; Vrábel, M.; Pohl, R.; Pivoňková, H.; Havran, L.; Hocek, M.; Fojta, M.: "Ferrocenylethynyl Derivatives of Nucleoside Triphosphates: Synthesis, Incorporation, Electrochemistry and Bioanalytical Applications" Chem. Eur. J. 2007, 13, 9527–9533.
3. Vrábel, M.; Pohl, R.; Klepetářová, B.; Votruba, I.; Hocek, M.: "Synthesis of 2'-deoxyadenosine nucleosides bearing bipyridine-type ligands and their Ru-complexes in position 8 through cross-coupling reactions" Org. Biomol. Chem. 2007, 5, 2849–2857.
2. Vrábel, M.; Hocek, M.; Havran, L.; Fojta, M.; Votruba, I.; Klepetářová, B.; Pohl, R.; Rulíšek, L.; Zendlová, L.; Hobza, P.; Shih, I.; Mabery, E.; Mackman, R.: "Purines Bearing Phenanthroline or Bipyridine Ligands and Their RuII Complexes in Position 8 as Model Compounds for Electrochemical DNA Labeling – Synthesis, Crystal Structure, Electrochemistry, Quantum Chemical Calculations, Cytostatic and Antiviral Activity" Eur. J. Inorg. Chem. 2007, 1752-1769.
1. Čapek, P.; Vrábel, M.; Hasník, Z.; Pohl, R.; Hocek, M.: "Aqueous-Phase Suzuki-Miyaura Cross-Coupling Reactions of Free Halopurine Bases" Synthesis 2006, 3515-3526.
© Michal Hocek
Institute of Organic Chemistry and Biochemistry
Academy of Sciences of the Czech Republic