Novel types of modified derivatives and analogues of nucleobases, nucleosides, nucleotides and nucleic acids are designed and prepared for applications in all areas of biomedicinal sciences (medicinal chemistry, biochemistry, chemical biology, bioanalysis etc.).
Basic developments of methodology for the synthesis of these modified biomolecules are performed largely using modern methods (including metal- or enzyme-catalyzed reactions). Biological activity (cytostatic, antiviral etc.) of the novel nucleobases, nucleosides and nucleotides is systematically studied in collaboration with several groups both in academia and in pharmaceutical industry. Several collaborative projects also address chemical biology of nucleic acids (i.e. DNA polymerase specificity and fidelity). Functionalized nucleic acids bearing diverse interesting and useful substituents are another goal of our group. For details, see Projects.
Tichý, M. et al: "Synthesis and Cytostatic and Antiviral Profiling of Thieno-Fused 7-Deazapurine Ribonucleosides" J. Med. Chem. 2017, 60, 2411 – 2424.
Downey, A. M. et al: "Synthesis of Nucleosides through Direct Glycosylation of Nucleobases with 5-O-Monoprotected or 5-Modified Ribose: Improved Protocol, Scope, and Mechanism" Chem. Eur. J. 2017, 23, 3910 – 3917.
Matyašovský, J. et al: "2-Substituted dATP Derivatives as Building Blocks for Polymerase-Catalyzed Synthesis of DNA Modified in the Minor Groove" Angew. Che. Int. Ed. 2016, 55, 15856 - 15859.
9.2.2016 Dr. Dmytro Dziuba has completed his postdoctoral studies at IOCB and went to EMBL Heidelberg as an EIPOD postdoctoral fellow.
4.2.2016 Dr. Pavel Kielkowski (former PhD student in our group) received the Werner von Siemens Award for the best PhD thesis.
22.1.2016 Martin Klečka has defended PhD.